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some key Publications

Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Ramos Y, Rice SJ, Ali SA, Pastrello C, Jurisica I, Thomas Appleton C, Rockel JS, Kapoor M. Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies. December 2023. PubMed.

Sandhu A, Espin-Garcia O, Rockel JS, Lively S, Perry K, Mohamed NN, Raja Rampersaud Y, Perruccio AV, Robin Poole A, Gandhi R, Kapoor M. Association of synovial fluid and urinary C2C-HUSA levels with surgical outcomes post-total knee arthroplasty. October 2023. PubMed

Sandhu A, Rockel JS, Lively S, Kapoor M. Emerging Molecular Biomarkers in Osteoarthritis Pathology. Therapeutic Advances in Musculoskeletal Disease. June 2023. Sage Journals

Rockel JS, Kapoor M. Understanding synovial cell diversity in post- traumatic OA. Nature Reviews Rheumatology. November 2022. PubMed

Tavallaee G, Lively S, Rockel JS, Ali SA, Im M, Sarda C, Mitchell GM, Rossomacha E, Nakamura S, Potla P, Gabrial S, Matelski J, Ratneswaran A, Perry K, Hinx B, Ghandi R, Jurisica I, Kapoor M. Contribution of microRNA-27b-3p to synovial fibrotic responses in knee osteoarthritis. July 2022. Arthritis & Rheumatology

Ali S, Espin-Garcia O, Kin On Wong A, Potla P, Pastrello C, McIntyre M, Lively S, Jurisica I, Gandhi R, Kapoor M. Circulating microRNAs differentiate fast-progressing from slow-progressing and non-progressing knee osteoarthritis in the Osteoarthritis Initiative cohort. Therapeutic Advances in Musculoskeletal Disease. March 2022. Sage Journals

 Ali SA, Peffers M, Ormseth MJ, Jurisica I, Kapoor M. The noncoding RNA interactome in joint health and disease. September 2021. Nature Reviews Rheumatology

Helal Endisha, Poulami Datta, Anirudh Sharma, Sayaka Nakamura, Evgeny Rossomacha, Carolen Younan, S. Amanda Ali, Ghazaleh Tavallaee, Starlee Lively, Pratibha Potla, Konstantin Shestopaloff, Jason S. Rockel, Roman Krawetz, Nizar N. Mahomed, Igor Jurisica, Rajiv Gandhi and Mohit Kapoor. MicroRNA-34a-5p promotes joint destruction during Osteoarthritis. Arthritis and Rheumatology. September 2020. Arthritis & Rheumatology

Amanda Ali, Rajiv Gandhi, Pratibha Potla, Sareh Keshavarzi, Osvaldo Espin-Garcia, Konstantin Shestopaloff, Chiara Pastrello, Dylan Bethune-Waddell, Starlee Lively, Anthony Perrucci, Raja Rampersaud, Christian Veillette, Jason Rockel, Igor Jurisica, Tom Appleton, Mohit Kapoor. Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis. Osteoarthritis and Cartilage. July 2020. Science Direct

Jason Rockel, Brian Wu, Sayaka Nakamura, Evgeny Rossomacha, Osvaldo Espin-Garcia, Rajiv Gandhi, Mohit Kapoor. TAT-Beclin-1 induces severe synovial hyperplasia and does not protect from injury-induced osteoarthritis in mice. Osteoarthritis and Cartilage. July 2020. Science Direct

Akihiro Nakamura, Shabana Amanda Ali, Mohit Kapoor. Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks. Bone; June 2020. Science Direct

Mohit Kapoor. Mechanisms of Fibrosis. Seminars in Cell and Developmental Biology. PubMed

Anusha Ratneswaran, Jason Rockel and Mohit Kapoor. Integration of multi-omics strategy for osteoarthritis phenotyping. Current Opinion in Rheumatology. 2020 Jan;32(1):80-91. doi: 10.1097/BOR.0000000000000680. PubMed

Nakamura A, Rampersaud YR, Nakamura S, Sharma A, Zeng F, Rossomacha E, Ali SA, Krawetz R, Haroon N, Perruccio AV, Mahomed NN, Gandhi R, Rockel JS, Kapoor M. microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints. Annals of the Rheumatic Diseases. 2018 Oct 4. pii: annrheumdis-2018-213629. doi: 10.1136/annrheumdis-2018-213629. PubMed | Highlighted in Nature Rewiews Rheumatology

Endisha H, Rockel J, Jurisica I, Kapoor M. The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets. Journal of Clinical Investigation Insight. 2018 Sep 6;3(17). pii: 121630. doi: 10.1172/jci.insight.121630. PubMed

Lietman C*, Wu B*, Lechner S, Shinar A, Sehgal, M, Rossomacha, E, Sharma, A, Gandhi, R, Mohit Kapoor and Pampee Young.(2017). Inhibition of Wnt/β-Catenin signaling ameliorates osteoarthritis in a murine model of experimental OA. Journal of Clinical Investigation Insight; 2018 Feb 8;3(3). pii: 96308. doi: 10.1172/jci.insight.96308. PubMed 

*equal first author contribution

David Lagares, Parisa Ghassemi-Kakaroodi, Caroline Tremblay, Daniela M. Santos, Paula Grasberger, Neil Ahluwalia, Clemens K. Probst, Sydney B. Montesi, Barry S Shea, Katharine E. Black, Rachel Knipe, Meryem Blati, Murray Baron, Brian Wu, Hassan Fahmi, Rajiv Gandhi, Annie Pardo, Moisés Selman, Jiangping Wu, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Andrew M. Tager and Mohit Kapoor. ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis. Nature Medicine. 2017. 23, 1405–1415. PubMed

David Lagares, Alba Santos, Paula E. Grasberger, Fei Liu, Clemens K. Probst, Rod A. Rahimi Norihiko Sakai, Tobias Kuehl, Jeremy Ryan, Patrick Bhola, Joan Montero, Mohit Kapoor, Murray Baron, Xaralabos Varelas, Daniel J. Tschumperlin, Anthony Letai, and Andrew M. Tager. Targeted apoptosis of myofibroblasts with the BH3 Mimetic ABT-263 reverses established fibrosis. Science Translational Medicine. Published. 2017, December; 9:420. doi: 10.1126/scitranslmed.aal3765 PubMed

Poulami Datta, Yue Zhang, Alexa Parousis, Anirudh Sharma, Evgeny Rossomacha, Izabela Kacprzak, Brian Wu, Nizar N. Mahomed, Rajiv Gandhi, Jason S. Rockel and Kapoor Mohit. High-fat diet-induced acceleration of osteoarthritis is associated with sustained metabolite signature regulated by Leptin/Autotaxin pathway.  Published. Nature Scientific Reports. 2017 August 15. doi: 10.1038/s41598-017-07963-6. PubMed

Rockel J and Kapoor M. Autophagy: Controlling cell fate in Rheumatic Diseases: Nature Review Rheumatology. 2016. Epub. doi:10.1038/nrrheum.2016.92. PubMed

A. Nakamura, Y. R. Rampersaud, A. Sharma, S.J. Lewis, B. Wu, P. Datta, K. Sundararajan, H. Endisha, E. Rossomacha, J. Rockel, I. Jurisica, and M. Kapoor. (2016). Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration. Journal of Clinical Investigation Insight. 2016(1): 12. PubMed

Ying‐Hua Li, Ghazaleh Tavallaee, Tomas Tokar, Akihiro  Nakamura, Kala Sundararajan, Amanda Weston, Anirudh Sharma, Nizar N. Mahomed, Rajiv Gandhi, Igor Jurisica and Kapoor M. Identification of synovial fluid microRNA signature in knee OA: Differentiating early‐and late‐stage knee osteoarthritis. Osteoarthritis and Cartilage. 2016 April 30. pii: S1063‐ 4584(16)30057‐7 doi: 10.1016/j.joca.2016.04.019  PMID: 27143365. PubMed

Vasheghani F, Zhang Y, Yinghua Li, Meryem Blati, Hassan Fahmi, Bertrand Lussier, Peter Roughley, David Lagares, Daniel Lajeunesse, K. Wayne Marshall, Raja Rampersaud, Nizar N. Mahomed, Rajiv Gandhi, Jean-Pierre Pelletier, Johanne Martel-Pelletier and Kapoor M. PPARgamma deficiency results in severe accelerated Osteoarthritis associated with defective mTOR and autophagy signalling. Annals of The Rheumatic Diseases. 2015 Mar. 74(3):569-78. PMID: 25573665 PubMed

Zhang Y, Vasheghani F, Li YH, Blati M, Simeone K, Fahmi H, Lussier B, Roughley P, Lagares D, Pelletier JP, Martel-Pelletier J, Kapoor M. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from Osteoarthritis. Annals of the Rheumatic Diseases. 2015 Jul;74(7):1432-40 doi: 10.1136/annrheumdis-204599. PMID: 24651621. PubMed

Book: Editors: Kapoor M and Mahomed N.N. (2015). Osteoarthritis: Pathogenesis, diagnosis, available treatments, drug safety, Regenerative and Personalized Medicine. Kapoor M and Nizar Mahomed. Publisher: ADIS. Springer

Yuen YH, Lagares D, Tager AM and Kapoor M. Fibrosis- A lethal component of rheumatic diseases. Nature Reviews Rheumatology: 2014 Jul;10(7):390- 402. doi: 10.1038/nrrheum.2014.53 PMID: 24752182. PubMed

Vasheghani F , Monemdjou R , Fahmi H , Zhang Y , Perez G , Blati M , St-Arnaud R , Pelletier JP , Beier
F , Martel-Pelletier J , Kapoor M. (2013). Adult Cartilage-Specific Peroxisome Proliferator-Activated Receptor Gamma Knockout Mice Exhibit the Spontaneous Osteoarthritis Phenotype. The American Journal of Pathology. 182(4): 1099-1106. PubMed

Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M. (2012). Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. Arthritis and Rheumatism. 64(5): 1551-1561. PubMed

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. (2011). Role of Proinflammatory Cytokines in the Pathophysiology of Osteoarthritis. Nature Reviews Rheumatology. 7(1): 33-42. PubMed

For a full list of publications, please follow this link.

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